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En stor mengde knowledge fra gravide indikerer hverken misdannelser eller toksisitet av paracetamol hos foster/nyfødt barn. Paralgin forte/Paralgin main skal bare brukes less than graviditet hvis fordel oppveier mulig risiko, og da med lavest mulig effektiv dose i kortest mulig tid og lavest mulig frekvens.
- This medicine can only be used for the temporary procedure of acute moderate soreness when other agony killers haven't worked.
Stoff som reduserer eller opphever virkningen av et annet stoff i organismen. Brukes ved behandling av overdosering/forgiftninger.
Incorporates paracetamol. Do not just take with other paracetamol-made up of solutions. Fast health care guidance needs to be sought while in the occasion of the overdose Even when you feel perfectly due to the risk of delayed, critical liver damage.
In experiments performed because of the Nationwide Toxicology Method, fertility assessments happen to be performed in Swiss mice in a ongoing breeding research. No outcomes on fertility were seen. Use in pregnancy and nursing
This drug is classified as being a pregnancy Class C drug. There are no ample and well-managed experiments completed in Expecting Females. Codeine really should only be made use of in the course of pregnancy In case the likely reward outweighs the possible risk of your drug into check here the fetus . Codeine has shown embryolethal and fetotoxic outcomes during the hamster, rat along with mouse styles at about two-4 periods the most suggested human dose .
The pupils might be pin-position in measurement; nausea and vomiting are frequent. Hypotension and tachycardia are feasible but unlikely.
Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.
Perfenazin hemmer omdannelsen fra kodein til den aktive metabolitten morfin by way of CYP2D6 og vil dermed kunne gi nedsatt analgetisk effekt av kodein.
Tilstand som skyldes inntak av giftige stoffer, slik som legemidler, rusmidler, kjemikalier eller stoffer som finnes naturlig i dyr og planter, i en slik mengde at det kan fileøre til alvorlig skade.
Article-operative use in kids There are already experiences in the printed literature that codeine provided put up-operatively in little ones immediately after tonsillectomy and/or adenoidectomy for obstructive slumber apnoea, brought about exceptional, but daily life-threatening adverse functions like Loss of life (see also section four.
ninety % ved samtidig bruk av rifampicin, at den reduseres med ca. 70 % ved samtidig bruk av rifapentin (daglig dosering), og at den reduseres med 30-40 % samtidig bruk av rifabutin. Siden den induserende effekten av rifapentin er doseavhengig, vil dosering for eksempel en gang hver tredje dag eller en gang ukentlig vil gi en lavere påvirkning enn daglig dosering.
Nonetheless, When the affected person is an extensive or ultra-immediate metaboliser there is a heightened chance of building side effects of opioid toxicity even at normally prescribed doses. These sufferers convert codeine into morphine promptly resulting in increased than envisioned serum morphine stages.
Children with compromised respiratory perform Codeine will not be suggested for use in young children in whom respiratory purpose may be compromised which includes neuromuscular Issues, extreme cardiac or respiratory problems, upper respiratory or lung infections, numerous trauma or in depth surgical processes. These elements could worsen signs and symptoms of morphine toxicity.